Which drug is right for you? Do you know if you are responding to the drug?
The company is developing a novel, rapid, point of care diagnostic testing platform. The first products are platelet function tests specific to measuring the effectiveness of certain drugs like aspirin, Brilinta, Effient and Plavix. Personalized medicine means "...Right patient, delivered in the right dose and at the right time." - John Lechleiter, CEO Eli Lilly.
Click here to view CNN Video that explains the clinical need for platelet function testing.
"Buyers will want to ration drug use, particularly of innovative product, so therapies that can identify the right patient will be attractive." Eli Lilly: Recreating Drug Discovery for the 21st Century Other new anti-platelet drugs competing with Plavix are Brilinta® (AstraZeneca) and Effient® (Daiichi-Sankyo, Lilly), that are more effective than Plavix for some patients, but have an increased risk of bleeding¹⁶
Approximately 1 in 3 patients may not respond adequately to their antiplatelet drugs. For those who are non-responders, there is a significantly greater risk of a heart attack, MI, stroke or death⁴⁻⁶. Specific to aspirin, studies indicate non-responders are 4 times more likely to experience a heart attack, stroke or death⁷.
MARKET: A case for Phenotype testing
Which is right for you: Plavix? Or Effient? Or Brilinta? Or Aspirin or a combination?
“We’ve always had platelet function testing available with the gold standard, light transmission aggregometry. Using that method, I can tell if the patient’s inhibited, whether they’re on aspirin, clopidogrel, or prasugrel, but I can’t do it quickly,” said Sanfelippo. “It takes anywhere from an hour-and-a-half to two hours to complete, from the time the blood arrives in the lab.”* - Marshfield Labs
“If a patient’s baseline is
60 percent inhibition, we know we’ll probably
have to wait at least five days prior to
going to surgery. If they’re that high, we’ll
start testing every 24 hours until they get to
less than 20 percent. On the other hand, if
their baseline is 28 percent,
we’ll test every 12 hours,
or even every six hours.*” –Huntsville Hosp.
The standard therapy has been aspirin plus clopidogrel (brand name Plavix) for 2-6 months after bare metal stents and a year or more after drug-eluting stents.
But in July 2009, the FDA approved a new and more potent antiplatelet drug: prasugrel (brand name Effient). One caution about prasugrel has been that, because it is more powerful, it may have pose an increased risk of bleeding complications for the patient.
Effient: “Compared to clopidogrel (Plavix), prasugrel inhibits adenosine diphosphate–induced platelet aggregation more rapidly, more consistently, and to a greater extent than do standard and higher doses of clopidogrel in healthy volunteers and in patients with coronary artery disease, including those undergoing PCI“ -Wiviott SD, Braunwald E, McCabe CH et al (2007). "Prasugrel versus clopidogrel in patients with acute coronary syndromes". N Engl J Med 357 (20): 2001–15. doi:10.1056/NEJMoa0706482
Brilinta was approved by the US Food and Drug Administration on July 20, 2011 “Ticagrelor is the only one in the group that has shown a reduction in mortality, and I always put a lot of weight into that. Saving lives is what you want to do,” Faxon said. “The bleeding rates are probably more significant than the papers would have you realize, but it seems to have a better profile than prasugrel. It has a relatively short half-life. So you can administer the drug and it works right away, and you can stop it and it goes away very quickly.” -David P. Faxon, MD, vice chair of medicine for strategic planning at the Brigham and Women’s Hospital, Boston, and Cardiology Today Editorial Board member
Other Drugs: cangrelor, an IV-administered thienopyridine that is a direct and reversible P2Y12 inhibitor. This drug has the advantage of having an even more rapid onset and offset than ticagrelor due to IV administration.
Basic FAQ and Background of Platelets and Drugs:
Why do we take Aspirin?
How can we test for platelet
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